15. NWO Applied and Engineering Sciences (NWO-TTW) project (16105) "ReaSONS 2 Demo: Realtime Sensing of Neural Signals to Demonstrator" (2017 --), project leader: prof.dr.ir. W.A. Serdijn.
We recently developed a radically new technique, coined "additive companding", which solves important technological limitations of current neural recording systems. The technology has been patented, tested in the lab as proof of concept and is now ready to be developed further into a prototype. The foreseen prototype will allow for continuous and complete monitoring of neural activity, offers better performance and consumes drastically less volume (<400 µm x 400 µm x 400 µm) and energy (<<1 mW) than neural monitoring systems that currently exist or are under development. Clinically, the continuous and complete neural monitoring will offer new insights into the exact workings of nerve and brain tissue and it becomes possible to take the first step into the development of active medical implants that adjust themselves to the therapeutical needs of the patient without subjective measures. This, ultimately, enhances the health-related quality of life of patients with nerve and/or brain disorders and allows for a better treatment of a larger variety of nerve and brain disorders.
14. Dutch Technology Foundation (STW) and (Hartstichting) project (14728) "AFFIP -- Atrial Fibrillation FIngerPrinting: Spotting Bio-Electrical Markers to Early Recognize Atrial Fibrillation by the Use of a Bottom-Up Approach" (2016 --), project leader: dr. N.M.S. de Groot (ErasmusMC), workpackage leader WP4, High Density Mapping Array: prof.dr.ir. W.A. Serdijn. Atrial fibrillation (AF) is a progressive disease and associated with severe complications such as stroke. The goal of this project is to develop age and gender based, bio-electrical diagnostic tests, the invasive and non-invasive AF Fingerprint, which consists of electrical atrial signal profiles and levels of atrial specific tissue/blood biomarkers. In daily clinical practice, this novel diagnostic instrument can be used for early recognition or progression of AF by determination of stage of the electropathology. As such, AF Fingerprinting enables optimal AF treatment, thereby improving patient’s outcome.
13. Dutch Technology Foundation (STW) project (13598) "Digitally Dominant Analog Blocks for Ultra-Low-Power Wireless Sensor Network" (2016 --), project leader: prof.dr.ing. L.C.N. de Vreede (TU Delft), workpackage leader WP2 and WP4: prof.dr.ir. W.A. Serdijn. The progress of ultra-low-cost, ultra-low-power (ULP) wireless sensor network (WSN) nodes with advanced bi-directional communication, sophisticated sensors and powerful digital processing is hindered by the continued lack of digitization of its two major subsystems: frequency synthesizers (both providing radio-frequency carrier and clock to the digital processor) and power management converters. This work aims to address these concerns by investigating and demonstrating digitally intensive ULP solutions of all-digital phase-locked loops (ADPLL) and inductor/capacitor-based DC-DC switching converters.
12. EU ECSEL JU project "InForMed -- An Integrated Pilot Line for Medical Devices" (2015 --), project leader: dr. S. Swaving. Wouter Serdijn is involved in WP4, Demonstrator 2: Advanced devices for electrophysiology. In the InForMed project an integrated pilot line for medical devices will be established, covering the complete innovation chain from technology concept to system qualification. It will include micro-fabrication, assembly and even the fabrication of smart catheters. Uniquely, the integrated pilot line is hosted by a large industrial end-user, and is specifically targeted and equipped to bridge the gap in the landscape of micro-fabrication of medical devices between concept creation and full-scale production.
11. Research Program "MASSIVE -- Autonomous Vital Signs Monitoring" (2013 -- ), program leader: prof.dr.ir. W.A. Serdijn. In this research program, supported by CNPq, CAPES, CSC and Delft University of Technology, we work on electroceuticals that wirelessly receive power and wirelessly transmit vital signs like body temperature, ECG, EMG, EEG and ECoG.
10. Research Program "SINs -- Smart Implantable Neurostimulators" (2009 -- ), TUD program leader: prof.dr.ir. W.A. Serdijn. In this research program that is a collaboration of Delft University of Technology (4 sections, 3 departments), Erasmus University Rotterdam, Dunedin School of Medicine, Otago University, University of Texas at Dallas, the Brain Research center for Advanced, Innovative and Interdisciplinary Neuromodulation and Irion Technologies, we push the research and development of technology for research on and treatment of a multitude of brain disorders, a.o., tinnitus and addiction.
9. Dutch Technology Foundation (STW) project (11693) “REASONS – Realtime Sensing of Neural Signals” (2011 – ), project leader: prof.dr.ir. W.A. Serdijn. This project targets the development of a completely new readout system for measuring the so called electrically evoked compound action potential (eCAP) coming from the auditory nerve. To develop this readout system, new electronic circuitry will be designed based on state of the art technologies integrated with the electrode itself. Existing systems will be tested extensively to develop novel measurement algorithms for the new readout system. Animal experiments will be performed on existing and new readout systems. We expect to come up with circuits and systems for reading out neural responses that offer more functionality, better performance and enjoy a drastically reduced form factor and power consumption. Clinically, the neural response will give new insight in the potential of eCAP recordings and take the first step in moving toward fitting to the patient without subjective data. Future patients will be rehabilitated better and faster with the newly developed methods.
8. STW project (10056) “SMAC-IT – Smart Implantable Cochlear Implants” (2008 – 2013). Dr. Serdijn has been workpackage leader in the STW project SMAC-IT, funded as part of the SMART-SIP program. In this project, research has been conducted and technologies developed to address the drawbacks of current cochlear implants by: (i) greatly increasing the number of electrodes with low level processing at each electrode, (ii) by optimization of electrode use after implantation using remote wireless connection, (iii) by investigating a feedback system to also monitor the reaction of the nerve during implantation, and (iv) devise microactuators to simplify the device placement and improve safety.
7. STW Valorization Grant (Phase 1) project (07880) “AIR-MARKET: Autocorrelation Impulse Radio to the Market” (2007), project leaders: dr. G. Leus and dr. W.A. Serdijn. Within this project, we investigated the development of a completely new generation of impulse-radio UWB systems based on the new design principles and (convincing) proofs-of-principle recently developed at Delft University of Technology. These principles solve the main problems associated with the current generation of impulse-radio UWB systems. The aim of the AIR-MARKET project was: (i) to consolidate all the necessary components into a coherent database of design objects, incl. architecture definition, system data, VHDL descriptions, circuit schematics, integrated circuits, implemen-tation and application notes, use cases, simulation and measurement results; and (ii) to develop a (prototype) chip set that will form the basis for the development of special applications in security, localization and telemetry systems.
6. STW project (DTC.6438) “McAT – Multi-carrier Adaptive Transceivers” (2004 – 2011), project leader: dr. W.A. Serdijn. In this project, design methodologies for the adaptive analog RF front-end of OFDM transceivers, i.e., the part of the transceiver that accommodates the varying channel, have been developed; and modulation and channel-coding techniques for OFDM transceivers, to be applied in the part of the transceiver that accommodates the varying user and application requirements, have been developed. The techniques and methodologies developed in this project have beenvalidated by both a specification and an implementation of a broadband wireless communication transceiver at 17 GHz that achieves the lowest power consumption from a system point of view for a guaranteed performance under varying application and channel conditions. The project was supported by TNO, SystematIC, Philips Research (now NXP) and National Semiconductor (now TI).
5. STW project (DTC.6418) “BioSens – Biomedical Signal Processing Platform for Low-Power Real Time Sensing of Cardiac Signals” (2004 – 2009), projectleader: dr. W.A. Serdijn. This project, by means of i) the mathematical modeling of cardiac signals and pathologies, ii) the design of WT-based algorithms for intelligent sensing and feature extraction, and iii) the development of low-power analog integrated circuits that implement the required wavelet transform and artifact detection, taking into account the limitations imposed by an implantable device, produced, apart from scientific publications, the materialization of the scientific research efforts into validated prototypes of pacemaker and implantable cardio defibrillator front-ends. The project’s primary user was Medtronic. Other users of the project were: Vitatron, Maastricht Instruments, SystematIC Design, Weijand R&D Consultancy and Twente Medical Systems International.
4. Freeband Impulse project (DTC.5961) “AIR-LINK” (2002 – 2007). Dr. Serdijn has been workpackage leader in the Freeband Impulse project "AIR-LINK" (Ad-hoc Impulse Radio -- Local Instantaneous NetworK), aiming at high-quality, wireless short-distance communication, employing Ultra-Wide Band radio. In the AIR-LINK project unique, groundbreaking scientific research has been done on the performance analysis and design of UWB transceivers and networks employing autocorrelation. Users of the project were: ASTRON, National Semiconductor, Intersil, Agere Systems, WMC, Philips, Vodafone and the Ministry of Defense. The results of the project are being valorized by 3UB B.V.
3. STW project (DEL.3943) “Design and Realisation of Electronic Systems and Circuits for subminiature hearing aids with strongly directional microphone arrays” (1998 – 2003), project leaders: dr. A.C. van der Woerd and dr. W.A. Serdijn. In this project, a first step towards the development of a pair of hearing spectacles was made. The project enjoyed an active utilization committee, comprising representatives from Amsterdam Medical Center, Amsterdam / Duran Audio BV, Zaltbommel / SonionMicrotronic Nederland BV, Amsterdam / Nederlandse Vereniging voor Slechthorenden, Houten / Beltone Netherlands BV, Eindhoven. Results of the project were described in a patent application (EP 0 924 958 A1) describing the inventions that form the basis of the "Varibel".
2. UBICOM project (1997-2002): Dr. Serdijn has been project leader in the Ubiquitous Communications (UbiCom) project of Delft University of Technology. The UbiCom project has laid to a solid foundation for multidisciplinary research in personal mobile computing and communications. The participating research groups were active in UbiCom in the following discipline fields: (i) micro-electronics for low-power wireless communications transceivers, (ii) signal processing for high bandwidth high frequency wireless communications, (iii) multimedia (video and graphics) processing, (iv) sensor data (video and location signals, GIS databases) analysis and fusion for context awareness, (v) augmented reality display technology and usability, (vi) quality of service architectures, (vii) quality of service protocols and programming.
1. STW project (DEL33.3251) “Ultra Low-Power Electronics” (1994 – 1998), project leader: dr. W.A. Serdijn. Within this project design methodologies and proof-of-concepts have been developed for low-power low-voltage circuits for biomedical systems, such as wearable, implantable and injectable devices, among them being hearing instruments and pacemakers. Major design constraints that were taken into account are reliability, low-voltage (1 – 3 volt) and ultra low-power (<< 1mW) operation. The project enjoyed an active utilization committee, comprising representatives from Amsterdam Medical Center, Twente University, Ericsson, Vitatron Medical, Philips Semiconductors and Philips Hearing Instruments (now Beltone).